Journal Name: Indo Global Journal of Pharmaceutical Sciences
Special Issue: Natural Products in Medicinal Chemistry
Special Issue Guest Editors:
Dr. Luciana Scotti
Federal University of Paraíba, Campus I; 58051-970, João Pessoa, PB, Brazil.
E-mail: [email protected]
Prof. Marcus TulliusScotti
Federal University of Paraíba, Department of Engineering and the Environment, Campus IV; 58297-000, Rio Tinto, PB, Brazil .
Submission deadline: 15th October, 2015.
Tentative submission of issue: 15th December, 2015
Scope and Objective:
The use of product naturals has been the subject of increasing interest in phytochemistry, biochemistry and other fields of research at the chemistry-biology-ecosystems interface. These compounds are naturally present in vegetables, fruits and they are important components of the daily diet. They are also common constituents of medicinal plants, and the therapeutic effects of many traditional medicines have been attributed to these phytochemicals.Some natural products are phenolic compounds, flavonoids, alkaloids, terpenes, secondary metabolites of plants that cause several benefits to our health .
Virtual structure-based screening has become prominent in drug discovery. Also, several free natural ligand databases are widely available today. Using homology of peptides, crystallographic or modeled protein structures, molecular docking is often employed to screen compound libraries and to predict the conformation of a protein-ligand complex and calculate its affinity energy. Targeting these interactions with small molecule inhibitors as well as searches for new targets is of increased interest for therapeutic purposes of several diseases.
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The objective for this thematic issue is to report recent studies about different approaches using natural productsin medicinal chemistry applied to drug discovery, that comprises synthesis, semi-synthesis,searches for new targets, evaluation of biological activities, and/or theoretical approaches as structure-based approaches, SAR, QSAR, docking and several cheminformatics methods . These efforts that involve several studies to aid the discovery of new legends to treatment or cure of diseases.
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- Ooms, F. Molecular modeling and computer aided drug design. Examples of their applications in medicinal chemistry. Med. Chem., 2000, 7(2),141-158.